Gadd45a Promotes Skeletal Muscle Atrophy


Gadd45a Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4

Skeletal muscle atrophy is a serious and highly prevalent condition that remains poorly understood at the molecular level.  We found that Gadd45a interacts with multiple proteins in skeletal muscle fibers, including, most prominently, the MAP kinase kinase kinase MEKK4.

  • Spectral Viewer for MS/MS spectra of phosphorylated peptides from MEKK4, and selected 'One-peptide-wonders' of other kinases.  Go To zip file on Panorama.
  • Supplemental Tables and Supplemental Figure (attached)