LipidCreator: A workbench to probe the lipidomic landscape
Peng B, Kopczynski D, Pratt BS, Ejsing CS, Burla B, Hermansson M, Benke PI, Tan SH, Chan MY, Torta F, Schwudke D, Meckelmann SW, Coman C, Schmitz OJ, MacLean B, Manke MC, Borst O, Wenk MR, Hoffmann N, Ahrends R. LipidCreator workbench to probe the lipidomic landscape. Nat Commun. 2020 Apr 28;11(1):2057. doi: 10.1038/s41467-020-15960-z. PMID: 32345972; PMCID: PMC7188904.
- Organism: Homo sapiens
- Instrument: Q Exactive HF,QTRAP 6500
- SpikeIn:
Yes
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Lab head: Robert Ahrends
Submitter: Robert Ahrends
We developed LipidCreator, the first software fully supporting targeted lipidomics assay development. LipidCreator offers a comprehensive framework to compute MS/MS fragment masses of over 60 lipid classes. LipidCreator provides all functionalities to define fragments, manage stable isotope labeling, optimize collision energy and generate in-silico spectral libraries. LipidCreator proved to be an efficient tool for investigating phospholipid derived mediators to dissect lipid-signaling pathways of human platelets during activation.
Experiment descriptions are available from the following MetaboLights submissions:
Targeted Mediator Profiling, QTRAP: https://www.ebi.ac.uk/metabolights/MTBLS1381
DIA Validation, QEx-HF: https://www.ebi.ac.uk/metabolights/MTBLS1382
Targeted Phospho- and Glycerolipid Profiling, QEx-HF: https://www.ebi.ac.uk/metabolights/MTBLS1369
Sample descriptions are available from the following MetaboLights submissions:
Targeted Mediator Profiling, QTRAP: https://www.ebi.ac.uk/metabolights/MTBLS1381
DIA Validation, QEx-HF: https://www.ebi.ac.uk/metabolights/MTBLS1382
Targeted Phospho- and Glycerolipid Profiling, QEx-HF: https://www.ebi.ac.uk/metabolights/MTBLS1369
Created on 1/29/20, 2:47 PM