LINCS Overview

 

    Our Compounds

 

Set 1:

Epigenetically Active

 

Set 2:

NeuroActive

 

Set 3:

Ser/Thr Kinase pathways

        

Common Name

MOA

 

Common Name

MOA

 

Common Name

MOA

DMSO

negative control

 

DMSO

negative control

 

DMSO

negative control

GSK1210151A

Bromodomain inhibitor; BRD2,3,4

 

Etoposide

Top2B inhibitor, DNA DSB inducer

 

Selumetinib

Mek1/2 inhibitor

GSK525762A

Bromodomain inhibitor; BRD2,3,4

 

KU-55933

ATM inhibitor

 

PD0325901

Mek1/2 inhibitor

jq1

Bromodomain inhibitor; BRD4

 

SMER-3

E3 ligase inhibitor

 

Everolimus

mTOR inhibitor

zebularine

DNMT1 inhibitor

 

ruxolitinib

JAK 1 & 2 inhibitor

 

vemurafenib

Raf inhibitor

decitabine

DNMT1 inhibitor

 

niclosamide

STAT3 signaling inhibitor

 

TG101348

Jak2 inhibitor

EPZ-5676

DOT1L inhibitor

 

VU0155056

inhibitor of phospholipase D1/D2

 

Tofacitinib

Jak3 inhibitor

EPZ004777

DOT1L inhibitor

 

tacrolimus

inhibitor of calcineurin

 

Pravastatin

Stat1 inhibitor

gsk126

EHZ2 inhibitor

 

tretinoin

Retinoic Acid Receptor agonist

 

SCH 900776

Rep. stress/CHK1 inhibitor

EPZ-5687

EHZ2 inhibitor

 

curcumin

NFkB inhibitor

 

flavopiridol

CDK inhibitor

CPI-169

EHZ2 inhibitor

 

semagacestat

gamma secretase inhibitor

 

PD-0332991

CDK/4,6 inhibitor

UNC0646

G9a inhibitor

 

dexamethasone

Glucocorticoid receptor agonist

 

Dinaciclib

CDK/1,2,5,9 inhibitor

UNC0321

G9a inhibitor

 

Olaparib

PARP inhibitor

 

RO4929097

Notch/gamma secretase inhibitor

BIX 01338

G9a inhibitor

 

bafilomycin A1

inhibitor of the vacuolar-type H+-ATPase

 

BMS-906024

Notch/other inhibitor

BIX 01294

G9a inhibitor; ? also kinase inhibitor (mTOR)

 

Exifone

Antioxidant

 

Verteporfin

Hippo inhibitor

vorinostat

HDAC inhibitor; general

 

vorinostat

HDAC inhibitor; general

 

SP600125

Jnk inhibitor

entinostat (MS275)

HDAC inhibitor; general

 

KN-62

CaMKIIalpha inhibitor

 

vorinostat

HDAC inhibitor; general

tacedinaline (Ci-994)

HDAC inhibitor; general

 

calpain inhibitor II

calpain inhibitor

 

CC-401

Jnk inhibitor

trichostatin-a

HDAC inhibitor; general

 

C646

CBP/p300 inhibitor

 

VX-970

Rep. stress/ATR inhibitor

belinostat

HDAC inhibitor; general

 

Compound E

gamma secretase inhibitor

 

losmapimod

p38 MAPK inhibitor

methylstat

JHDM inhibitor (Jumonji C)

 

KN-93

CaMKII/CaMKIV inhibitor

 

PRI-724

Notch/Wnt/Hedgehog inhibitor

GSK-J4

JMJD3 inhib

 

Gossypetin

HDAC1 activator

 

dactolisib

Ras/PI3K inhibitor

UNC1215

L3MBTL3 probe

 

Ginkgetin

HDAC1 activator

 

afuresertib

Ras/AKT inhibitor

1271738-62-5 (MI-2)

MLL inhibitor

 

Okadaic Acid

PP1 and PP2a inhibitor

 

BYL719

Ras/PI3K-P110a inhibitor

OSI-027

mTOR inhibitor

 

momelotinib

JAK1/2 inhibitor

 

Pazopanib

PDGFR and VEGFR; Also c-KIT, FGFR, inhibitor

resveratrol

SirT1 activator (?)

 

TBB

Casein kinase II inhibitor

 

Nilotinib

Multikinase inhibitor

EX527

SirT1 inhib

 

Roscovitine

Cdk5 inhibitor

 

lenalidomide

immunomodulator

salermide

SirT1 inhib; SirT2 inhib

 

Rolipram

PDE4 inhibitor

 

AR A014418

GSK3 inhibitor

geldanamycin

HSP90 inhibitor

 

RGFP966

HDAC3 inhibitor

 

BMS-345541

IkKB inhibitor

rapamycin

mTOR inhibitor

 

sotrastaurin

inhibitor of protein kinase C beta

 

IPI-145

Ras/PI3K-P110g,d inhibitor

staurosporine

Kinase inhibitor; general

 

staurosporine

Kinase inhibitor; general

 

staurosporine

Kinase inhibitor; general

LY-294002

Kinase inhibitor; pim-1, PI3k

 

CHIR99021

GSK3 inhibitor

 

PS-1145

IkK inhibitor

 

 

Download the LINCS PCCSE Poster (2015)


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