Next Generation Translational Proteomics of Alzheimer's Disease

2021-04-12

Overview

Alzheimer's disease (AD) is a major, growing global public health problem. This is a daunting scientific challenge and solutions will come only from innovative research. We have brought together a unique interdisciplinary team of investigators with the goal of bridging the divide between state-of-the-art technologies and translational applications.

Our U19 research program will consist of four projects and four cores that are synergistic to our mission. Moreover, our research team is uniquely suited to the development, validation and translational application of new biomolecular assays to reflect AD pathophysiology.

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Learn more about each project or core by clicking on the icons below!


Project1

Project 1

Discovery of proteins with altered abundance and stability.

Project2

Project 2

Highly multiplexed particle and brain mapping of CSF proteins.

Project3

Project 3

Identification of mass spectrometric targets and development of multiplex assays for disease management.

Project4

Project 4

Novel reagent development to facilitate characterization of proteins of neuropathological importance.

Core1

Core 1

Administrative Core
Core2

Core 2
Clinical Resource Core
Core3

Core 3
Affinity Reagent Characterization Core
Core4

Core 4
Statistical Analysis and Data Dissemination Core