Figure 5B (middle&rightpanel), 5C Error cluster induced by different aminoglycosides

Figure 5 Distance dependence of successive errors

(B)   Distance dependence of error cluster formation. Left panel: Distance dependence Ef(next)  for Apr, Par and Str. Data from Figures 4A,D, 5A, S7A, and S8. The probability for error cluster formation are normalized to that of Str value, which is almost not distance-dependent and is set to 1 (Methods). Error bars represent the standard deviation of the mean between different error clusters. The number of cluster are indicated in the circles. Middle and right panel: Distance dependence of error cluster formation for different AGA based on PRM measurements. Each point represents a mean value of up to three error clusters.

(C)   Correlation between Ef(first) and Ef(next)  for different AGAs. Data are from (B). Only clusters with adjacent substitutions are considered (F47L-D48E; E241D-E242D). Color code as in Figure 5B.


 

Clustergrammer Heatmap
 
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Distance 3 NeoB_2020-04-30_12-17-20.sky.zip2020-05-21 11:30:156610905
Distance 3 Nea_2020-04-30_12-15-32.sky.zip2020-05-21 11:30:1599151384
Distance 3 KanB_2020-04-30_12-12-41.sky.zip2020-05-21 11:30:1566101046
Distance 3 KanA_2020-04-30_12-08-46.sky.zip2020-05-21 11:30:156610955
Distance 3 Tob_2020-04-30_12-05-11.sky.zip2020-05-21 11:30:1566101005
Distance 3 Gen_2020-04-30_12-02-11.sky.zip2020-05-21 11:30:1599151655
Distance 3 Sis_2020-04-30_11-58-20.sky.zip2020-05-21 11:30:1599151805
Distance 3 Apr_2020-04-30_11-54-26.sky.zip2020-05-21 11:30:1599151745
Distance 3 Par_2020-04-30_11-47-18.sky.zip2020-05-21 11:30:1599152005
Distance 3 DHS_2020-04-29_16-55-43.sky.zip2020-05-21 11:30:1599151955
Distance 3 Str_2020-04-29_16-33-31.sky.zip2020-05-21 11:30:1599152054
Nea Distance 11_2020-04-29_16-30-18.sky.zip2020-05-21 11:30:15335554
Gen Distance 11_2020-04-29_16-28-18.sky.zip2020-05-21 11:30:15335555
Sis distance 11_2020-04-29_16-23-40.sky.zip2020-05-21 11:30:15335305
Apr Distance 11_2020-04-29_16-18-01.sky.zip2020-05-21 11:30:15335555
Par Distance 11_2020-04-29_16-14-24.sky.zip2020-05-21 11:30:14335905
DHS Distance 11_2020-04-29_16-12-44.sky.zip2020-05-21 11:30:14335905
Str Distance 11_2020-04-29_16-08-48.sky.zip2020-05-21 11:30:14335904
Distance 6 Nea_2020-04-29_16-06-09.sky.zip2020-05-21 11:30:14335404
Distance 6 KanA_2020-04-29_15-56-57.sky.zip2020-05-21 11:30:14335355
Distance 6 Tob_2020-04-29_15-55-38.sky.zip2020-05-21 11:30:14335485
Distance 6 Gen_2020-04-29_15-53-54.sky.zip2020-05-21 11:30:14335505
Distance 6 Sis_2020-04-29_15-51-13.sky.zip2020-05-21 11:30:14335455
Distance 6 Apr_2020-04-29_15-49-45.sky.zip2020-05-21 11:30:14335505
Distance 6 Par_2020-04-29_15-48-20.sky.zip2020-05-21 11:30:14335455
Distance 6 DHS_2020-04-29_15-46-56.sky.zip2020-05-21 11:30:14335505
Distance 6 Str_2020-04-29_15-44-52.sky.zip2020-05-21 11:30:14335504
Distance 4 Nea_2020-04-29_15-42-24.sky.zip2020-05-21 11:30:14335354
Distance 4 Tob_2020-04-29_15-39-24.sky.zip2020-05-21 11:30:14335205
Distance 4 Gen_2020-04-29_15-35-42.sky.zip2020-05-21 11:30:14335505
Distance 4 Sis_2020-04-29_15-34-20.sky.zip2020-05-21 11:30:14335455
Distance 4 Apr_2020-04-29_15-32-44.sky.zip2020-05-21 11:30:14335455
Distance 4 Par_2020-04-29_15-30-49.sky.zip2020-05-21 11:30:14335555
Distance 4 DHS_2020-04-29_15-29-11.sky.zip2020-05-21 11:30:14335605
Distance 4 Str_2020-04-29_15-27-28.sky.zip2020-05-21 11:30:14335604
Distance NeoB_2020-04-29_15-00-01.sky.zip2020-05-21 11:30:13335555
Distance 2 Nea_2020-04-29_14-55-01.sky.zip2020-05-21 11:30:13335504
Distance 2 KanB_2020-04-29_14-51-26.sky.zip2020-05-21 11:30:13335556
Distance 2 KanA_2020-04-29_14-49-31.sky.zip2020-05-21 11:30:13335555
Distance 2 Tob_2020-04-29_14-47-32.sky.zip2020-05-21 11:30:13335605
Distance 2 Gen_2020-04-29_14-45-44.sky.zip2020-05-21 11:30:13335605
Distance 2 Sis_2020-04-29_14-43-40.sky.zip2020-05-21 11:30:13335605
Distance 2 Apr_2020-04-29_14-38-54.sky.zip2020-05-21 11:30:13335605
Distance 2 Par_2020-04-29_14-34-25.sky.zip2020-05-21 11:30:13335605
Distance 2 DHS_2020-04-29_14-31-31.sky.zip2020-05-21 11:30:13335605
Distance 2 Str_2020-04-29_14-29-29.sky.zip2020-05-21 11:30:13335604
Distance 1 NeoB_2020-04-29_14-06-53.sky.zip2020-05-21 11:30:136610945
Distance 1 Nea_2020-04-29_13-53-48.sky.zip2020-05-21 11:30:136610704
Distance 1 KanB_2020-04-29_13-48-12.sky.zip2020-05-21 11:30:136610996
Distance 1 KanA_2020-04-29_13-41-38.sky.zip2020-05-21 11:30:1366101005
Distance 1 Tob_2020-04-29_13-39-20.sky.zip2020-05-21 11:30:1366101205
Distance 1 Gen_2020-04-29_13-35-35.sky.zip2020-05-21 11:30:1366101045
Distance 1 Sis_2020-04-29_13-30-18.sky.zip2020-05-21 11:30:1366101205
Distance 1 Apr_2020-04-29_13-27-09.sky.zip2020-05-21 11:30:1366101205
Distance 1 Par_2020-04-29_13-23-17.sky.zip2020-05-21 11:30:1366101205
Distance 1 DHS_2020-04-29_13-19-41.sky.zip2020-05-21 11:30:1366101205
Distance 1 Str_2020-04-29_13-15-11.sky.zip2020-05-21 11:30:1366101204